Traumatic Brain Injury and Risk of Dementia and Alzheimer’s Disease

A Comprehensive Guide to the Literature for Personal Injury Lawyers

Publisher: Medifocus Legal
Publication Date: November 24, 2022
Number of Pages: 116

Traumatic brain injury (TBI) is one of the common causes of death and disability worldwide with various long-term outcomes. In modern societies, TBI is typically the consequence of traffic crashes and falls, particularly in young children and the elderly. In the United States, an estimated 1.7 million people sustain a TBI annually, of which 275,000 require hospitalization and 52,000 die.

One of the most feared long-term consequences of TBI is the potential for developing dementia and Alzheimer’s disease (AD) at some time point post-injury. Previous studies have investigated the possible role of TBI in the subsequent development of dementia and AD, however, the results of these studies have been inconsistent.

In general, however, the cumulative body of data published in the medical and scientific literature suggests the following:

1. There is sufficient evidence of an association between moderate and severe TBI and dementia. In cases involving a single TBI sustained in early to midlife, the risk of dementia in later life is 2-to-4 fold higher compared to the general population.

2. The risk of dementia appears significantly higher in the setting of multiple TBI, known as chronic traumatic encephalopathy (CTE).

2. There is limited but suggestive evidence of an association between mild TBI (concussion) with loss of consciousness and dementia.

3. There is insufficient evidence to determine whether an association exists between mild TBI without loss of consciousness and dementia.

4. Although there is insufficient evidence to suggest a positive association between TBI and Alzheimer’s disease, this finding should be interpreted with caution. More well-designed studies are needed in the future to either support or refute this finding.

The MediFocus Literature Guide to Traumatic Brain Injury and Risk of Dementia and Alzheimer’s Disease is a comprehensive reference guide to the literature that is designed to provide personal injury lawyers with a detailed understanding of the available scientific evidence regarding the risk for developing these life-altering cognitive disorders based on the severity of a given TBI. This objective is accomplished by a comprehensive review of the peer-reviewed literature published over the past two decades about the risk of dementia and Alzheimer’s disease following a TBI as documented from individual case reports, cohort studies, meta-analysis, and major topical review articles.

Traumatic Brain Injury and Risk of Dementia and Alzheimer’s Disease is a one-of-a-kind literature reference Guide that includes:

• A comprehensive bibliography of 122 journal article references indexed in MEDLINE published in well respected medical and scientific journals.
• Online access to the abstracts (summaries) of the articles.
• Online access to the free full-text version of 64 articles.
• Links to full-text sources of other articles that are available for purchase directly from individual journal publishers.
• A unique “Author Directory” consisting of the names and institutional affiliations of experts who have published and have specialized knowledge about Traumatic Brain Injury and Risk of Dementia and Alzheimer’s Disease. The “Author Directory” is a valuable resource for quickly identifying and locating experts for case reviews, opinions, and testimony.

Select examples of topics that are covered by the articles referenced in this Guidebook include:

• Traumatic Brain Injury and Risk of Alzheimer’s Disease and Related Dementias in the Population.
• Investigating the relationship between mild traumatic brain injury and Alzheimer’s disease and related dementias: a systematic review.
• Mild Traumatic Brain Injuries and Future Risk of Developing Alzheimer’s Disease: Systematic Review and Meta-Analysis.
• Traumatic Brain Injury and Early Onset Dementia in Post 9-11 Veterans.
• Traumatic brain injuries among veterans and the risk of incident dementia: A systematic review & meta-analysis.
• Traumatic brain injury fast-forwards Alzheimer’s pathology: evidence from amyloid positron emission tomorgraphy imaging.
• Head injury and 25-year risk of dementia.
• Traumatic brain injury alters neuropsychiatric symptomatology in all-cause dementia.
• An update on the association between traumatic brain injury and Alzheimer’s disease: Focus on Tau pathology and synaptic dysfunction.
• Mild TBI in the elderly – risk factor for rapid cognitive impairment in Alzheimer’s disease
• Association of traumatic brain injury with dementia and memory decline in older adults in the United States.
• Associations of Race-Ethnicity and History of Traumatic Brain Injury With Age at Onset of Alzheimer’s Disease.
• Relationship of traumatic brain injury to chronic mental health problems and dementia in military veterans.
• Traumatic Brain Injury as a Risk Factor for Dementia and Alzheimer Disease: Critical Review of Study Methodologies.
• No association between head injury with loss of consciousness and Alzheimer disease pathology- Findings from the University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age.
• Failure to detect an association between self-reported traumatic brain injury and Alzheimer’s disease neuropathology and dementia.
• Increased Risk of Dementia in Patients with Craniofacial Trauma: A Nationwide Population- Based Cohort Study.
• Traumatic Brain Injury and Age of Onset of Dementia with Lewy Bodies.
• Study of U.S. Veterans Links Mild Traumatic Brain Injury to Dementia Risk.
• Association of Mild Traumatic Brain Injury With and Without Loss of Consciousness With Dementia in US Military Veterans.

The MediFocus Literature Guide on Traumatic Brain Injury and Risk of Dementia and Alzheimer’s Disease is available in two formats:
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